Self-reported symptoms of covid-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable
Frances M. K. WilliamsiD, Maxim B. FreidiniD, Massimo ManginoiD, Simon CouvreuriD, Alessia ViscontiiD, Ruth C. E. BowyeriD, Caroline Ivanne Le RoyiD, Mario FalchiiD, Olatz MompeóiD, Carole H. SudreiD, Richard DaviesiD, Christopher J. HammondiD, Cristina MenniiD, Claire Joanne StevesiD, Tim D. SpectoriD
Abstract
Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n=2633) completing the C-19 Covid symptom tracker app allowed classical twin studies of covid-19 symptoms including predicted covid-19, a symptom-based algorithm predicting true infection derived in app users tested for SARS-CoV-2. We found heritability for fever = 41 (95% confidence intervals 12-70)%; anosmia 47 (27-67)%; delirium 49 (24-75)%; and predicted covid-19 gave heritability = 50 (29-70)%.
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