In vivo reprogramming of cytotoxic effector CD8+ T cells via fractalkine-conjugated mRNA-LNP
Angela R. Corrigan, Shin Foong Ngiow, Maura Statzu, Amie Albertus, María Betina Pampena, Jayme M.L. Nordin, Stephen D. Carro, Justin L. Harper, Rachelle L. Stammen, Jennifer Wood, Houping Ni, Justin Su, Marziyeh Hajialyani, Vladimir V. Shuvaev, Víctor Alcalde, , Michael R. Betts
This study shows fractalkine-conjugated mRNA-LNP can target and modify CD8+ T cells in vivo, enabling transient expression of proteins like IL-2 and CD62L.
Science Immunology · May 29, 2026Peer-reviewedImmunology