Tynan P. Gardner

Predicted structure of the complete CPLANE complex reveals novel interactors and mechanisms of Jbts17 during ciliogenesis

The paper predicts the structure of the CPLANE complex and identifies novel interactors of Jbts17, revealing its role in ciliogenesis through in silico and experimental validation.

A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseases

The paper reconstructs the protein interactome of the Last Eukaryotic Common Ancestor and identifies new human gene-disease associations for bone density and congenital birth defects.

Tbx1 ortholog org-1 is required to establish testis stem cell niche identity in Drosophila

The paper shows that org1 is required for specifying niche cell identity in Drosophila testis, influencing islet to establish a functional stem cell microenvironment.

The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture

This study identifies RSG1/CPLANE2 as a causative gene for human ciliopathy and shows its role in ciliary transition zone assembly.