Author

Richard D. LeDuc

Children's Hospital Research Institute of ManitobaORCID 0000-0002-6951-2923Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Organism:rat· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Marietta JankiD· 2 shared Matthew KraljeviciD· 2 shared Richard KeijzeriD· 2 shared Arzu ÖztürkiD· 1 shared Arzu Ozturk Aptekmann· 1 shared Athanasios ZovoilisiD· 1 shared Ayesha SaleemiD· 1 shared Bryan A. KillingeriD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersDevelopmental Biology

Marietta JankORCID

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4 papers

Recent·Most cited

Developmental BiologyClinical and Translational MedicinePeer-reviewedSep 1, 2026

Dysregulated circRNA expression profile and associated miRNA sponging in abnormal lung development in congenital diaphragmatic hernia

Marietta Jank, Arzu Ozturk Aptekmann, Rina Tanaka…·Richard Keijzer

The paper identifies a unique circRNA signature in congenital diaphragmatic hernia (CDH) lung development, showing miRNA sponging effects and pathway overlaps between rat and human CDH.

DOI 10.1002/ctm2.70752

ratbulk RNA-seq

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NeurosciencebioRxivPreprintOct 7, 2025

Aggregation-prone alpha-synuclein proteoforms and dysregulated molecular signatures in the vermiform appendix of synucleinopathy patients

Ehraz Anis, Saima Zameer, Josh Wierenga…·Bryan A. Killinger

The paper examines alpha-synuclein aggregation and molecular changes in appendix tissues from synucleinopathy patients compared to controls.

DOI 10.1101/2025.10.07.680938

humanbulk RNA-seq

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BioinformaticsbioRxivPreprintSep 8, 2025

FindBacksplice: a Tool for Locating Circular RNA Backsplice Coordinates

Matthew Kraljevic, Arzu Öztürk, Marietta Jank…·Richard D. LeDuc

FindBacksplice locates circular RNA backsplice coordinates using BSJ sequences across any genome version and species.

1 citation

humanrat

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Cell BiologybioRxivPreprintSep 9, 2024

Identification of novel myokines and putative protein targets that mediate functional adaptations in response to chronic contractile activity induced skeletal muscle-extracellular vesicle treatment

Patience O. Obi, Tamiris F. G. Souza, Ying Lao…·Ayesha Saleem

The paper identifies novel proteins and pathways in skeletal muscle-derived extracellular vesicles following chronic contractile activity, suggesting their role in metabolic and anti-tumorigenic effects.

2 citations

mouseproteomics

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