Cancer BiologyNature CommunicationsPeer-reviewed
Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma
Dong Wang, Caitlin Ritz, Yuhuan Luo…·Rajeev Vibhakar
This study identifies CDK8 as a critical dependence in MYC-driven medulloblastoma, showing its role in regulating transcription and translation through mechanisms involving ribosome biogenesis and 4EBP1 phosphorylation.
5 citations