Elias Konstantine Halvas

Dynamic Antigen Expression and Intrinsic CTL Resistance in HIV Reservoir Clones

This study characterizes HIV reservoir clones and shows they can be culled by sustained CTL pressure, with some displaying intrinsic resistance linked to low oxidative stress.

HIV-1 envelopes from virions that persist in plasma on antiretroviral therapy show reduced susceptibility to autologous immunoglobulins and variable sensitivity to broadly neutralizing monoclonal antibodies

The paper examines HIV-1 envelopes from persistent plasma virus on ART, finding reduced autologous Ig neutralization and variable sensitivity to broadly neutralizing mAbs.

HIV-1 control in vivo is related to the number but not the fraction of infected cells with viral unspliced RNA

The paper compares the fraction and total number of HIV-infected cells with unspliced RNA in controllers and non-controllers, finding that viremic control is linked to fewer infected cells, not a lower fraction of infected cells with HIV usRNA.

HIV-1 Viremia Not Suppressible By Antiretroviral Therapy Can Originate from Large T-Cell Clones Producing Infectious Virus

The paper identifies large T-cell clones producing infectious HIV-1 virus as a source of non-suppressible viremia despite ART adherence and no drug resistance.