Mary F. Kearney

This study uses ultra-deep single-genome sequencing to show strong purifying selection in early HIV-1 infection, with limited early genetic divergence from founder viruses.

This study detects HIV-1 antisense transcripts in vivo, showing higher expression in ART-treated individuals compared to untreated ones, suggesting a regulatory role in viral expression.

The paper compares HIV-1 proviral defects in children and adults on ART, finding more deletions and defects in children, especially in env and tat regions.

The paper examines HIV-1 envelopes from persistent plasma virus on ART, finding reduced autologous Ig neutralization and variable sensitivity to broadly neutralizing mAbs.

The paper compares the fraction and total number of HIV-infected cells with unspliced RNA in controllers and non-controllers, finding that viremic control is linked to fewer infected cells, not a lower fraction of infected cells with HIV usRNA.

The paper identifies large T-cell clones producing infectious HIV-1 virus as a source of non-suppressible viremia despite ART adherence and no drug resistance.

HIV-DRLink detects linked HIV-1 drug resistance mutations in next-generation sequencing data to predict treatment failure.