Author

Tianchi Xin

Yale UniversityORCID 0000-0002-6982-8610Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:imaging· 2 Approach:statistical model· 2

Frequent Co-Authors

Valentina GrecoiD· 3 shared Chae Ho LimiD· 2 shared David G. GonzaleziD· 2 shared Eva-LaRue Barber· 2 shared Hainan Lam· 2 shared Katie CockburniD· 2 shared Kevin A. PetersoniD· 2 shared Lauren E. GonzaleziD· 2 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersGenetics

Valentina GrecoORCID

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5 papers

Recent·Most cited

Sharp cell type boundaries emerge from coordinated morphogen signaling

Ruiqi Li, Yiqun Jiang, Sarah Platt, Tianchi Xin, Shagun Lukkad, Sarah Van, Kevin A. Peterson, Ryan R. Driskell, Jonathan Zhu, Hainan Lam, Eva-LaRue Barber, David H. Wang, Chae Ho Lim, Makoto Mark Taketo, Yuval Kluger, Peggy S. Myung

The paper shows how coordinated Wnt and Hedgehog signaling creates sharp cell-type boundaries by synchronizing cell-cycle exit and differentiation.

Genes & Development · Sep 10, 2026Peer-reviewedDevelopmental Biology

Sharp cell-type boundaries emerge from temporal coordination between morphogen signals

Ruiqi Li, Yiqun Jiang, Sarah Platt, Tianchi Xin, Ryan Driskell, Kevin A. Peterson, Sarah Van, Hainan Lam, Shagun Lukkad, Eva-LaRue Barber, Chae Ho Lim, Makoto Mark Taketo, Yuval Kluger, Peggy S. Myung

The paper shows that coordinated timing between Wnt and Hedgehog signaling generates sharp cell-type boundaries during hair follicle development.

bioRxiv · Jun 29, 2025 · PreprintDevelopmental Biology

Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo

Dennis P. May, Sangwon Yun, David G. Gonzalez, Sang‐Bum Park, Yanbo Chen, Elizabeth Lathrop, Biao Cai, Tianchi Xin, Hongyu Zhao, Siyuan S. Wang, Lauren E. Gonzalez, Katie Cockburn, Valentina Greco

The paper uses live imaging to study chromatin compaction and transcriptional dynamics during stem cell differentiation in live mouse epidermis, showing that chromatin changes follow transcriptional activity.

eLife · Mar 7, 2023Peer-reviewedGenetics

Reorganizing Niche Architecture Still Preserves Organ Function in the Hair Follicle

Haoyang Wei, Shuangshuang Du, Jeeun Parksong, Hilda Amalia Pasolli, Sergi Regot, Lauren E. Gonzalez, Tianchi Xin, Valentina Greco

The paper shows that reorganizing the hair follicle niche architecture can still support organ function, though it may lead to premature differentiation and reduced hair production.

bioRxiv · Sep 6, 2022 · PreprintDevelopmental Biology

Epidermal stem cells self-renew upon neighboring differentiation

Kailin R. Mesa, Kyogo Kawaguchi, David G. Gonzalez, Katie Cockburn, Jonathan Boucher, Tianchi Xin, Allon M. Klein, Valentina Greco

This study shows that epidermal stem cells self-renew in response to neighboring differentiation, revealing coordinated fate decisions rather than autonomous or stochastic choices.

bioRxiv · Jun 25, 2017 · PreprintCell Biology