Peggy S. Myung

Sharp cell type boundaries emerge from coordinated morphogen signaling

The paper shows how coordinated Wnt and Hedgehog signaling creates sharp cell-type boundaries by synchronizing cell-cycle exit and differentiation.

LMD: Cluster-Independent Multiscale Marker Identification in Single-cell RNA-seq Data

LMD identifies localized genes in single-cell RNA-seq data to characterize cellular diversity without batch correction, outperforming existing methods.

Sharp cell-type boundaries emerge from temporal coordination between morphogen signals

The paper shows that coordinated timing between Wnt and Hedgehog signaling generates sharp cell-type boundaries during hair follicle development.

Gene Trajectory Inference for Single-cell Data by Optimal Transport Metrics

GeneTrajectory infers gene trajectories instead of cell trajectories to uncover progressive gene dynamics in biological processes.

Inference and analysis of cell-cell communication using CellChat

CellChat infers communication probabilities between cell groups using a mass-action model and 2,021 curated ligand-receptor interactions (multimeric complexes, cofactors), then compares signaling networks across scRNA-seq datasets.