David G. Gonzalez

Skin capillary endothelial cells form a network of spatiotemporally conserved Ca2+ activity

The paper uses intravital imaging to study Ca2+ activity in skin capillaries of live mice, revealing spatiotemporal organization and regulation through gap junctions and L-type Ca2+ channels.

Fibroblast depletion reveals mammalian epithelial resilience across neonatal and adult stages

This study shows that epidermal stem cell proliferative capacity remains unaffected by fibroblast depletion in both adult and neonatal skin, highlighting robust compensatory mechanisms.

A mitochondrial program encodes brain vascular reserve

The paper shows mitochondrial state in zebrafish tip cells encodes brain collateral network topology, with microRNA-125a regulating mitochondrial function to influence vascular resilience.

Mechanisms of vascular maturation and maintenance captured by longitudinal imaging of live mouse skin

This study uses longitudinal imaging to show how vascular maturation and maintenance occur in live mouse skin through vessel regression, EC rearrangement, and VEGFR2 signaling.

Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo

The paper uses live imaging to study chromatin compaction and transcriptional dynamics during stem cell differentiation in live mouse epidermis, showing that chromatin changes follow transcriptional activity.

Epidermal stem cells self-renew upon neighboring differentiation

This study shows that epidermal stem cells self-renew in response to neighboring differentiation, revealing coordinated fate decisions rather than autonomous or stochastic choices.