Kevin C. O’Connor

The paper identifies an intrathecal antibody response to EBV BRRF2 and human antigens in MS, showing cross-reactivity and association with increased IgG synthesis.

This study identifies elevated polyreactive and autoreactive B cells and impaired BCR signaling in NF155-AIN patients, suggesting distinct immunopathology compared to CIDP.

The paper presents high-resolution structures of the human muscle AChR and maps epitopes of MG autoantibodies to reveal diverse pathogenic mechanisms.

The paper improves the TIgGER algorithm to accurately identify subject-specific immunoglobulin alleles from AIRR-seq data, even when alleles differ by more than 5 SNPs from known database alleles.