Tead1 reciprocally regulates adult β-cell proliferation and function to maintain glucose homeostasis
Jeongkyung Lee, Ruya Liu, Byung S. Kim, Yiqun Zhang, Feng Li, Rajaganapti Jagannathan, Ping Yang, Vinny Negi, Joseph Danvers, Eliana Melissa Perez-Garcia, Pradip Saha, Omaima M. Sabek, Chad J. Creighton, Cristian Coarfa, Mark O. Huising, , Vijay K. Yechoor
This study shows TEAD1 regulates adult β-cell proliferation and function, maintaining glucose homeostasis by balancing quiescence and mature identity in mice and humans.
bioRxiv · Mar 5, 2020 · PreprintMolecular Biology