Development of iPSC-Derived T Cells Targeting EGFR Neoantigens in Non-Small Cell Lung Cancer
Kouta Niizuma, Toshinobu Nishimura, Jonathan Villanueva, Laura Amaya, Jonas L. Fowler, Taichi Isobe, Yusuke Nakauchi, Brandon Saavedra, Haojun Xu, Mahito Nakanishi, Adam C. Wilkinson, Kyle M. Loh, Joseph B. Shrager, Hiromitsu Nakauchi
This study develops iPSC-derived T cells targeting the EGFR C797S mutation in NSCLC, showing their ability to recognize and kill cancer cells expressing this mutation.
Molecular Therapy — Methods & Clinical Development · Jun 18, 2025Peer-reviewedImmunology