Hadi Boukhatmi

Delta/Notch signaling level is decoded through transcriptional burst duration during muscle progenitor specification

The paper shows that muscle progenitors decode Notch signaling levels through transcriptional burst duration, with higher Delta levels leading to stronger Notch signaling and distinct transcriptional outputs.

Cancer cachexia overrides sex-specific traits in Drosophila

This study shows that cancer cachexia in Drosophila reduces sex-specific differences in gene expression and metabolic profiles, leading to a shared molecular cachexic state.

SPARC mediates tumour-stroma intercellular communication through endosomal regulation of Delta and Notch signalling

This study identifies SPARC as a mediator of tumour-stroma communication by regulating endosomal Delta and Notch signalling in a Drosophila cancer model.

Immune vascular dialogue coordinates muscle maintenance following damage in Drosophila

This study identifies a novel immune-vascular communication program in Drosophila that coordinates muscle maintenance after damage through macrophage-derived signals and ECM organization.

N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity

The paper shows that N-terminal acetylation by NatC protects proteins from degradation, enhancing longevity and motility, and that UBR4-KCMF1 targets unacetylated N-terminal Met followed by hydrophobic residues.

A population of adult satellite-like cells in Drosophila is maintained through a switch in RNA-isoforms

The paper shows that Drosophila muscle progenitors maintain a satellite-like state by switching RNA-isoforms of zfh1, which protects them from differentiation.