Matthew M. Crane

The paper shows that loss of vacuolar acidity in yeast causes iron sulfur cluster defects and divergent iron homeostasis during aging.

This study edits rDNA replication origins in yeast using CRISPR/Cas9, revealing growth and lifespan consequences of such modifications.

The paper quantifies Intron Mediated Enhancement (IME) in C. elegans by measuring protein expression levels using fluorescent reporters and finds a single intron can increase expression by about 50%.

This study uses single-cell imaging to examine age-related genome missegregation in yeast, identifying rDNA expansion as a contributor to mitotic failures and nucleolar breakdown.

The paper introduces DISCO, a cell segmentation framework for microfluidic devices that improves tracking and segmentation by incorporating physical constraints and morphology, showing better performance than existing software.