Takahide Matsushima

Tendon-specific PIEZO1 activation enhances neural drive to muscle during ballistic movement

This study shows that tendon-specific PIEZO1 activation increases neural drive to muscle during high-load ballistic movements, without affecting muscle mass or myogenic gene expression.

NAT10 supports CAG repeat-associated mRNA stabilization and is associated with hepatic metabolic reprogramming during spaceflight

This study identifies NAT10 as a regulator of CAG repeat-containing mRNA stability and links its upregulation in spaceflight to metabolic reprogramming in mouse liver.

One-step generation of mice by Transposon-Enhanced Multi-Plex Orchestration Editing(TEMPO-Editing)

This study introduces TEMPO-editing, a method to generate multiple-gene-edited mice in a single step, demonstrating its effectiveness in creating double-gene-edited mice with spatial and temporal specificity.

Single-nucleus transcriptional and chromatin accessibility analyses of maturing mouse Achilles tendon uncover the molecular landscape of tendon stem/progenitor cells

This study identifies CD55 and CD248 as novel surface markers for tendon stem/progenitor cells using single-cell and single-nucleus sequencing in mouse Achilles tendon.

Transcriptome analysis of sevoflurane exposure effects at the different brain regions

This study identifies KLF4 as a potential transcriptional regulator of angiogenesis and neural development in sevoflurane-exposed mice brains.

The tRNA pseudouridine synthase TruB1 regulates the maturation and function of let-7 miRNA

The paper identifies TruB1 as a regulator of let-7 miRNA maturation and function, showing it enhances let-7 processing through direct interaction with pri-let-7.