Tomoaki Tanaka

NAT10 supports CAG repeat-associated mRNA stabilization and is associated with hepatic metabolic reprogramming during spaceflight

This study identifies NAT10 as a regulator of CAG repeat-containing mRNA stability and links its upregulation in spaceflight to metabolic reprogramming in mouse liver.

Organ-resolved endothelial regulatory programs link aging and metabolic overload to vascular immune remodeling

This study identifies organ-specific endothelial regulatory programs in aging and metabolic overload, revealing how vascular immune remodeling is coupled to local inflammatory restraint.

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis

Cholesterol accumulation in hepatic lipid droplets drives inflammation and fibrosis in mouse and human MASH and is reversed by inhibiting cholesterol synthesis or knocking down Coasy or Hsd17b13.