Marco Milán

A tumour-host feed-forward loop contributes to malignant growth in chromosomal instability-induced epithelial tumours

The paper shows that aneuploidy-induced senescent cells in Drosophila tumours secrete proteins that promote non-autonomous cell death, which in turn enhances tumour growth through feedback mechanisms.

A systemic role of macrophage-derived BMP2/4 homolog Dpp in regulating sterol hormone synthesis under dietary stress

The paper shows that macrophage-derived Dpp in Drosophila reduces ecdysone synthesis under high-sugar diet, prolonging larval development to allow optimal growth.

A pivotal contribution of proteostasis failure and mitochondrial dysfunction to chromosomal instability-induced microcephaly

This study identifies proteostasis failure and mitochondrial dysfunction as key factors in microcephaly caused by complex aneuploidies in neural stem cells.

Ribosome Quality Control Mitigates Proteotoxic Stress in Aneuploid Cells

The paper shows that ribosome quality control via ZNF598 degradation helps aneuploid cells survive proteotoxic stress, with ZNF598 expression linked to tumor aneuploidy.

Depletion of aneuploid cells is shaped by cell-to-cell interactions

The paper shows that aneuploid cells are out-competed by normal cells, and cell interactions influence their elimination during development and disease.

Eiger/TNFα-mediated Dilp8 and ROS production coordinate intra-organ growth in Drosophila

This paper identifies a two-step molecular mechanism involving Dmp53, Eiger, JNK, and ROS that coordinates intra-organ growth and proliferation in Drosophila.

Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila

The paper identifies Ask1 and Akt as synergistic regulators of ROS-dependent regeneration in Drosophila by sensing oxidative stress and modulating signaling pathways.