Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models
Marziyeh Belal, Tamara Perez‐Rosello, Elif Beyza Guven, Samet Kocatürk, Zhong Xie, Ema Ilijić, Tatiana Tkatch, J. Li, William T. Dauer, Maxime Assous, James M. Tepper, Vernon R. J. Clarke, Dalton James Surmeier
This study investigates how Parkinson's disease disrupts cholinergic interneuron control of GABAergic circuits in the striatum, showing reduced nicotinic AChR expression in interneurons in disease models.
bioRxiv · Jun 22, 2026 · PreprintNeuroscience