Vernon R. J. Clarke

This study investigates how Parkinson's disease disrupts cholinergic interneuron control of GABAergic circuits in the striatum, showing reduced nicotinic AChR expression in interneurons in disease models.

The paper identifies Ca2+-dependent phosphodiesterase 1 (PDE1) as a regulator of NO-induced long-term depression (NO-LTD) in striatal spiny projection neurons, linking it to synaptic plasticity and Parkinson's disease.

This study shows that Rem2 inhibits CaMKII activity at synapses, thereby restricting long-term potentiation in the hippocampus.

The paper investigates how GABAergic inputs modulate striatal spiny projection neuron excitability, showing that GABAARs can depolarize neurons in the resting down-state, enhancing responses to glutamatergic inputs.

This study shows that Sema4D treatment reduces seizure susceptibility and restores benzodiazepine sensitivity in a mouse model of Status Epilepticus.