Jérôme Baufreton

This study develops a mouse model of locus coeruleus alpha-synuclein overexpression to investigate early Parkinson's disease features, finding functional and neurochemical disruptions without neuronal loss.

The paper identifies distinct dopaminergic neuron populations projecting to the external Globus Pallidus and shows inhibitory control from the tVTA, revealing a disynaptic circuit.

This paper introduces a 3D neurosphere model from rodent brain cells to study synapse structure and function using advanced imaging and electrophysiology.

This study identifies a subset of dorsal raphe dopamine neurons (DRNVIP) critical for regulating threat assessment and defensive behaviors through feedback loops with the central extended amygdala.

This study examines developmental changes in indirect-pathway medium spiny neurons in HD mouse models, finding transient electrophysiological and anatomical alterations that may contribute to disease progression.

This study shows that blocking the CRF1 receptor in male mice prevents morphine-induced sociability deficits and oxytocinergic neuron firing, with sex-specific effects.

This study investigates the role of the subthalamic nucleus (STN) and its adjacent para-STN in behavioral avoidance using optogenetics and electrophysiology in mice.

This study examines how dopamine D1 receptor activation affects excitability of layer V pyramidal neurons in the primary motor cortex of young and adult mice, finding age-dependent differences.

This study identifies interhemispheric Insula neurons in mice and shows their role in social and anxiety processing through electrophysiology and circuit manipulation.

This study identifies a disynaptic circuit in the globus pallidus involving arkypallidal neurons that inhibits locomotion.

This study identifies the subthalamic nucleus (STN) as a critical hub for aversion, mediated through an STN-VP-LHb pathway.

This study shows that dopamine D2 receptors in parvalbumin interneurons of the mouse primary motor cortex increase neuronal excitability and GABAergic synaptic transmission to pyramidal neurons.

The paper investigates abnormal network dynamics in the GPe-STN circuit of Parkinsonian mice and identifies key changes in neuronal activity and connectivity.