Author

Elena V. Sineva

Pennsylvania State UniversityORCID 0000-0003-2307-0581Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:E. coli· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Aashish SrivastavaiD· 1 shared Abhishek MazumderiD· 1 shared Achillefs N. KapanidisiD· 1 shared Changsheng ZhangiD· 1 shared David DegeniD· 1 shared Dennis R. ThomasiD· 1 shared Diego Duchi· 1 shared Dongye Wang· 1 shared

Activity by Year

2018-2018 · peak 2/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Aashish SrivastavaORCID

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2 papers

Recent·Most cited

Molecular BiologyMolecular CellPeer-reviewedMar 29, 2018

Structural basis of transcription inhibition by fidaxomicin (lipiarmycin A3)

Wei Lin, Kalyan Das, David Degen…·Achillefs N. Kapanidis

This paper reports the cryo-EM structure of Mycobacterium tuberculosis RNAP holoenzyme bound to fidaxomicin, revealing its unique binding site and mechanism of transcription inhibition.

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experimental assay

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Molecular BiologyMolecular CellPeer-reviewedFeb 22, 2018

Allosteric effector ppGpp potentiates the inhibition of transcript initiation by DksA

Vadim Molodtsov, Elena V. Sineva, Lu Zhang…·Katsuhiko S. Murakami

This study reports the X-ray crystal structures of E. coli RNA polymerase complexes with DksA and ppGpp, revealing how ppGpp enhances DksA's inhibition of transcription initiation.

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E. coliprotein structure

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