Author

Shaohu Sheng

University of PittsburghORCID 0000-0002-7198-1702Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Thomas R. KleymaniD· 2 shared Aaliyah Winfrey· 1 shared Aidan W. PorteriD· 1 shared Alexa S. Jordahl· 1 shared Allison L. Marciszyn· 1 shared Andrew J. NickersoniD· 1 shared Annet KiraboiD· 1 shared Chunming Bi· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPhysiology

Thomas R. KleymanORCID

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2 papers

Recent·Most cited

Proteolytic Cleavage of the ENaC gamma Subunit: Impact Upon Na+ and K+ Handling

Evan C. Ray, Andrew J. Nickerson, Shaohu Sheng, Rolando Carrisoza‐Gaytan, Tracey R. Lam, Allison L. Marciszyn, Lei Zhang, Alexa S. Jordahl, Chunming Bi, Aaliyah Winfrey, Zhaohui Kou, Sébastien Gingras, Annet Kirabo, Lisa M. Satlin, Thomas R. Kleyman

This study investigates the impact of proteolytic cleavage of the ENaC gamma subunit on Na+ and K+ handling in mice, finding that cleavage is not essential for channel activity in vivo.

American Journal of Physiology-Renal Physiology · Apr 18, 2024Peer-reviewedPhysiology

Genome mining yields new disease-associated ROMK variants with distinct defects

Nga H. Nguyen, Srikant Sarangi, Erin M. McChesney, Shaohu Sheng, Jacob D. Durrant, Aidan W. Porter, Thomas R. Kleyman, Zachary W. Pitluk, Jeffrey L. Brodsky

The paper identifies new disease-associated ROMK variants using genomic databases and computational tools, revealing distinct molecular defects in protein folding and function.

PLoS Genetics · Nov 13, 2023Peer-reviewedGenetics