Jacob D. Durrant

Genome mining yields new disease-associated ROMK variants with distinct defects

The paper identifies new disease-associated ROMK variants using genomic databases and computational tools, revealing distinct molecular defects in protein folding and function.

Worth the weight: Sub-Pocket EXplorer (SubPEx), a weighted-ensemble method to enhance binding-pocket conformational sampling

SubPEx improves binding-pocket conformational sampling using weighted ensemble methods, demonstrating effectiveness on drug discovery targets.

Prot2Prot: A Deep Learning Model for Rapid, Photorealistic Macromolecular Visualization

Prot2Prot converts simple molecular representations into photorealistic images using deep learning, matching industry-standard 3D graphics results faster and more efficiently.

Defining the Yeast Resistome through in vitro Evolution and Whole Genome Sequencing

The paper identifies genetic determinants of chemical resistance in yeast using in vitro evolution and whole genome sequencing, revealing key transcription factors involved in drug resistance.

MutantHuntWGS: A Pipeline for Identifying Saccharomyces cerevisiae Mutations

MutantHuntWGS is a pipeline for analyzing Saccharomyces cerevisiae whole-genome sequencing data, identifying causal variants and providing reproducible results through containerization.