Leszek Kaczmarek

BDNF signaling requires Matrix Metalloproteinase-9 during structural synaptic plasticity

The paper shows MMP-9 is essential for structural long-term potentiation by cleaving proBDNF into mature BDNF and activating TrkB.

Lcn2 deficiency leads to social impairments independent of maternal immune activation.

This study shows that Lcn2 deficiency causes social impairments in offspring independent of maternal immune activation, with no additive effects when combined.

Activation of trace amine-associated receptor 1 (TAAR1) transiently reduces alcohol drinking in socially housed mice

This study shows that activating TAAR1 reduces alcohol consumption in mice, suggesting it as a potential target for treating alcohol abuse.

Celloscope: a probabilistic model for marker-gene-driven cell type deconvolution in spatial transcriptomics data

Celloscope deconvolves cell types in spatial transcriptomics data using marker genes, outperforming existing methods and accurately identifying brain structures and immune infiltrates.

Epileptiform GluN2B-driven excitation in hippocampus as a therapeutic target against temporal lobe epilepsy

This study investigates the role of GluN2B-containing NMDARs in temporal lobe epilepsy and suggests ifenprodil as a potential antiepileptic treatment.

Plasmin-mediated cleavage of EphA4 at central amygdala inhibitory synapses controls anxiety

This study identifies plasmin-mediated cleavage of EphA4 at central amygdala inhibitory synapses as a mechanism controlling anxiety through modulation of GABA-receptor anchoring and dendritic spine morphology.

A whole-brain imaging-based systems approach to understand origin of addiction in binge-like drinking model

The paper uses whole-brain imaging and c-Fos analysis in mice to study changes in brain networks during alcohol reexposure in a binge-like drinking model.

Serum response factor is essential for synaptic maturation in the hippocampus

This study shows that serum response factor (SRF) is crucial for dendritic spine maturation and social behavior, with its deletion causing spine immaturity and social deficits in mice.

c-Fos-MMP-9 pathway in central amygdala mediates approach motivation but not reward consumption

The paper investigates the role of c-Fos and MMP-9 in the central amygdala, finding they mediate approach motivation but not reward consumption.

Deciphering defective subventricular adult neurogenesis in cyclin D2-deficient mice

The paper investigates reduced adult neurogenesis in cyclin D2-deficient mice, identifying specific precursor cell population dysregulation and reduced interneuron numbers in the olfactory bulb.

Amot regulates neuronal dendritic tree through Yap1

This study shows Amot and Yap1 regulate dendritic tree morphogenesis in neurons, with Amot mediating this process through interactions with Yap1.