BDNF signaling requires Matrix Metalloproteinase-9 during structural synaptic plasticity
Diana Legutko, Łukasz Bijoch, Grzegorz Olszak, Bożena Kuźniewska, Katarzyna B. Kalita, Ryohei Yasuda, Leszek Kaczmarek, Piotr Michaluk
The paper shows MMP-9 is essential for structural long-term potentiation by cleaving proBDNF into mature BDNF and activating TrkB.
Science Advances · Sep 24, 2025Peer-reviewedNeuroscience