Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling
Grace Uwase, Priya Luthra, Olivia A. Vogel, Jyoti Batra, Bruno La Rosa, Kathleen C. F. Sheehan, Oam U. Khatavkar, Jacqueline E. Payton, Robert A. Davey, Nevan J. Krogan, Christopher F. Basler, Daisy W. Leung, Gaya K. Amarasinghe
This study identifies and characterizes the NNLNS motif in Ebola virus VP35 that mediates MIB2 binding, inhibiting IFN production and affecting viral RNA synthesis.
Proceedings of the National Academy of Sciences · Sep 22, 2025Peer-reviewedMicrobiology