Gaya K. Amarasinghe

Phenuivirus glycoprotein Gc domain is a conserved target of cross-functional monoclonal antibodies

This study isolates and characterizes monoclonal antibodies against Toscana virus's Gc glycoprotein, identifying cross-reactive antibodies that protect against Rift Valley Fever Virus.

Oropouche virus causes acute hepatitis in mice controlled by Type I interferons

This paper establishes two mouse models of Oropouche virus-induced hepatitis, showing that Type I interferons control disease severity and that contemporary isolates are less pathogenic than historical strains.

Characterization of neural infection by Oropouche orthobunyavirus

This study characterizes Oropouche orthobunyavirus replication in neural cells and brain slices, showing cytokine production and providing a model for studying viral neuropathogenesis.

Lrp1 facilitates infection of neurons by Jamestown Canyon virus

This study identifies Lrp1 as a host factor required for Jamestown Canyon virus infection of neurons and shows it is shared by other bunyaviruses.

Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling

This study identifies and characterizes the NNLNS motif in Ebola virus VP35 that mediates MIB2 binding, inhibiting IFN production and affecting viral RNA synthesis.

Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics

This study uses single-cell image-based CRISPR screens to identify host factors regulating Ebola virus infection, revealing new therapeutic targets like UQCRB and STRAP.

Peptide-antibody Fusions Engineered by Phage Display Exhibit Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants

This paper describes the engineering of peptide-antibody fusions using phage display to enhance neutralization potency and breadth against SARS-CoV-2 variants.

Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations

This paper develops tetravalent SARS-CoV-2 neutralizing antibodies that are more potent and resistant to escape mutations than bivalent versions.