Robert A. Davey

This study investigates the antiviral activity and mechanism of 4'-fluoroadenosine against viral and host polymerases, showing broad-spectrum inhibition and potential for drug development.

This paper uses yeast two-hybrid screens to identify EBOV-human protein interactions, revealing PABPC1 as a host factor required for viral replication.

This study identifies and characterizes the NNLNS motif in Ebola virus VP35 that mediates MIB2 binding, inhibiting IFN production and affecting viral RNA synthesis.

This study uses single-cell image-based CRISPR screens to identify host factors regulating Ebola virus infection, revealing new therapeutic targets like UQCRB and STRAP.

This study investigates how Ebola virus infects and accumulates in skin tissues of infected animals, identifying TIM-1 as a critical host receptor for viral dissemination.

This study identifies dermal cell types that support Ebola virus infection and shows how the virus traffics to the skin surface.

This study demonstrates that Ebola virus VP24 undergoes nuclear trafficking via IMPA and its nuclear export signal (NES) is critical for nucleocapsid formation and infectivity.

This study identifies genetic pathways involved in remdesivir cytotoxicity using CRISPR-Cas9 screening and transcriptomics, finding that SLC29A3 and AK2 are key factors in toxicity and efficacy.