Kathleen C. F. Sheehan

Personalized Neoantigen Vaccines Synergize with Immune Checkpoint Therapy and CD8-Targeted Cytokines to Control B-Cell Lymphoma

This study shows that personalized neoantigen vaccines combined with immune checkpoint therapy and CD8-targeted cytokines effectively control B-cell lymphoma by enhancing T-cell responses and preventing dysfunction.

Immune Checkpoint Therapy Drives Maturation of a Cellular Neighborhood Nucleated by T Cell-APC Triads Enabling Spatially Compartmentalized Tumor Immunity

The paper uses multiplex imaging to track the development of T cell-APC triad neighborhoods during immune checkpoint therapy, showing their role in spatially organizing tumor immunity.

Ebola virus VP35 NNLNS motif modulates viral RNA synthesis and MIB2-mediated signaling

This study identifies and characterizes the NNLNS motif in Ebola virus VP35 that mediates MIB2 binding, inhibiting IFN production and affecting viral RNA synthesis.

Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics

This study uses single-cell image-based CRISPR screens to identify host factors regulating Ebola virus infection, revealing new therapeutic targets like UQCRB and STRAP.