The paper identifies ortholog-restricted cysteines in Z. tritici that are targeted by stereoprobes, revealing potential fungicidal targets for combating wheat pathogens.

bioRxiv · Feb 17, 2026 · PreprintBiochemistry

A large European diversity panel reveals complex azole fungicide resistance gains of a major wheat pathogen

Guido Puccetti, Thomas Badet, Daniel Flückiger, Dominique Edel, Alice Feurtey, Camille Delude, Emile Gluck‐Thaler, Stefano F. F. Torriani, Gabriel Scalliet, Daniel Croll

This study analyzes a large European diversity panel of Zymoseptoria tritici to uncover genetic mechanisms underlying azole fungicide resistance across space and time.

mBio · Nov 24, 2025Peer-reviewedMicrobiology

High-throughput discovery of emerging antifungal resistance in crop pathogens

Guido Puccetti, Daniel Flückiger, Dominique Edel, Camille Delude, Sabina Moser Tralamazza, Thomas Badet, Gabriel Scalliet, Daniel Croll

This study develops a high-throughput pipeline to discover antifungal resistance in crop pathogens, identifying 2192 resistance-associated genes across a thousand-genome panel of Zymoseptoria tritici.

bioRxiv · Jul 18, 2025 · PreprintMicrobiology

Improved gene annotation of the fungal wheat pathogen Zymoseptoria tritici based on combined Iso-Seq and RNA-Seq evidence

Nicolas Lapalu, Lucie Lamothe, Yohann Petit, Anne Génissel, Camille Delude, Alice Feurtey, Leen Abraham, Daniel P. Smith, Robert King, Alison Renwick, Mélanie Appertet, Justine Sucher, Andrei Stecca Steindorff, Stephen B. Goodwin, Gert H. J. Kema, , Marc‐Henri Lebrun

The paper improves gene annotation of Zymoseptoria tritici by combining Iso-Seq and RNA-Seq data, resulting in more accurate gene models and new insights into its transcriptional landscape.

Molecular Plant-Microbe Interactions · Jan 1, 2025Peer-reviewedGenomics

SATAY-Based Chemogenomic Screening uncovers Antifungal Resistance Mechanisms and Key Determinants of ATI-2307 and Chitosan Sensitivity

Matthew T Karadzas, Agnès H. Michel, Andreas Mosbach, George Giannakopoulos, Ruairi McGettigan, Gabriel Scalliet, Benoı̂t Kornmann

This study uses SATAY to identify antifungal resistance mechanisms and key determinants of ATI-2307 and Chitosan sensitivity in yeast.

bioRxiv · Sep 20, 2024 · PreprintMicrobiology

A thousand-genome panel retraces the global spread and climatic adaptation of a major crop pathogen

Alice Feurtey, Cécile Lorrain, Megan C. McDonald, Andrew Milgate, Peter Scott Solomon, Rachael Warren, Guido Puccetti, Gabriel Scalliet, Stefano F. F. Torriani, Lilian Gout, Thierry C. Marcel, Frédéric Suffert, Julien Alassimone, Anna Lipzen, Yuko Yoshinaga, , Daniel Croll

The paper analyzes a thousand-genome panel of Zymoseptoria tritici to trace its global spread and identify genetic changes associated with climatic adaptation.

Nature Communications · Feb 24, 2023Peer-reviewedGenomics

CRISPR/Cas with ribonucleoprotein complexes and transiently selected telomere vectors allows highly efficient marker-free and multiple genome editing in Botrytis cinerea

Thomas Leisen, Fabian Bietz, J.A. Werner, Alex Wegner, Ulrich Schaffrath, David Scheuring, Felix Willmund, Andreas Mosbach, Gabriel Scalliet, Matthias Hahn

This paper introduces a CRISPR/Cas system using ribonucleoprotein complexes and telomere vectors for efficient marker-free genome editing in Botrytis cinerea, achieving high editing rates and enabling multiple edits.

PLoS Pathogens · Aug 17, 2020Peer-reviewedGenetics