Expanding the chemical diversity of RNA by transcriptional incorporation of amino acid- and glycosyl-modified nucleotides
Julián Valero, Kevin Neis, Laia Civit, Søren Fjelstrup, Maria Gockert, Jørgen Kjems
The paper demonstrates the enzymatic synthesis of chemically modified RNA using a mutant T7 RNA polymerase and evaluates the impact of modifications on transcription efficiency and fidelity.
bioRxiv · May 22, 2026 · PreprintMolecular Biology