Author

Nicholas David James

Institute of Cancer ResearchORCID 0000-0002-7314-8204Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:spatial transcriptomics· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ananya ChoudhuryiD· 3 shared Emma HalliD· 3 shared Robert Anthony HuddartiD· 3 shared Alexander R. BakeriD· 2 shared Amy BurleyiD· 2 shared Anna Clare WilkinsiD· 2 shared Catharine WestiD· 2 shared Conrado Guerrero QuilesiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

Ananya ChoudhuryORCID

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 22, 2026

Spatially-resolved multimodal profiling identifies functionally-heterogeneous cancer-associated fibroblasts associated with poor radiotherapy outcomes in muscle-invasive bladder cancer.

Amy Burley, Katie O’Fee, Morgane Dromby…·Anna Clare Wilkins

This study identifies functionally heterogeneous cancer-associated fibroblasts in muscle-invasive bladder cancer linked to poor radiotherapy outcomes.

DOI 10.64898/2026.09.18.752662

mousebulk RNA-seq

𝕏 PostBluesky

PathologybioRxivPreprintJul 1, 2026

Development of a multiplex immunofluorescence panel to study heterogenous cancer-associated fibroblast subtypes with spatial resolution

Amy Burley, Tatiany Silveira, Nicholas David James…·Anna Clare Wilkins

1 citation

humanimaging

𝕏 PostBluesky

Cancer BiologybioRxivPreprintApr 8, 2025

Fractionated radiation alters the extracellular matrix produced by muscle-invasive bladder cancer cells

Conrado Guerrero Quiles, S. Fahy, Michalina Bartak…·Ananya Choudhury

This study shows fractionated radiation changes the extracellular matrix (ECM) composition in muscle-invasive bladder cancer, with ECM-related genes linked to poor prognosis.

DOI 10.1101/2025.04.08.647735

humanproteomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintApr 4, 2025

Hypoxia-induced extracellular matrix changes are conserved in cancer and directly impact radiotherapy benefit

Conrado Guerrero Quiles, A. Julia Gonzalez, Arnaud Foussat…·Catharine West

The paper identifies hypoxia-induced ECM changes across cancers and shows they predict radiotherapy benefit.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky