Author

Dario DiFrancesco

University of MilanORCID 0000-0002-7322-1790Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Alessandro PorroiD· 2 shared Andrea SaponaroiD· 2 shared Anna MoroniiD· 2 shared Gerhard ThieliD· 2 shared Roberta CastelliiD· 2 shared Albano C. MéliiD· 1 shared Amitav Parida· 1 shared Ana Maria GomeziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPathology

Alessandro PorroORCID

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2 papers

Recent·Most cited

Comprehensive classification of HCN1 variants linked to neurodevelopmental disorders with and without epilepsy

Roberta Castelli, Carla Marini, Alessandro Porro, Anna Castellini, Greta Fontana, Andrea Saponaro, Gianpiero L. Cavalleri, Susanna Rizzi, Carlo Fusco, Amitav Parida, Richard C. Caswell, Charlotte Sherlaw, Dario Pruna, Christopher A. Reid, Lauren E. Bleakley, , Anna Moroni

This study functionally classifies HCN1 variants in patients with neurodevelopmental disorders, finding genotype-phenotype correlations and potential therapeutic targets.

bioRxiv · Mar 20, 2026 · PreprintPathology

Animal-free recombinant nanobody rescues HCN4 channel deficit in sinus node dysfunction

Atiyeh Sadat Sharifzadeh, Roberta Castelli, Alessandro Porro, Pietro Mesirca, Romain Perrier, Ana Maria Gomez, Hugo Benoit, Albano C. Méli, Luca Maria Giovanni Palloni, Dario DiFrancesco, Matteo Elia Mangoni, Gerhard Thiel, Andrea Saponaro, Anna Moroni

This study identifies a recombinant nanobody that specifically activates HCN4 channels and rescues sinus node dysfunction in a patient with a loss-of-function mutation.

bioRxiv · Mar 20, 2025 · PreprintBiophysics