BiochemistrybioRxivPreprint
Activity-based profiling of primary brain cells identifies covalent allosteric modulators of HCN channels
Elva Ye, Alberto Russo, Roberta Castelli…·Benjamin F. Cravatt
DOI 10.64898/2026.08.25.747126
Author
Roberta Castelli
University of MilanORCID 0009-0000-6773-7486Unclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
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2025-2026 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 34 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship3 papers
Recent·Most cited
- PathologybioRxivPreprint
Comprehensive classification of HCN1 variants linked to neurodevelopmental disorders with and without epilepsy
Roberta Castelli, Carla Marini, Alessandro Porro…·Anna Moroni
This study functionally classifies HCN1 variants in patients with neurodevelopmental disorders, finding genotype-phenotype correlations and potential therapeutic targets.
DOI 10.64898/2026.03.18.712601 - BiophysicsbioRxivPreprint
Animal-free recombinant nanobody rescues HCN4 channel deficit in sinus node dysfunction
Atiyeh Sadat Sharifzadeh, Roberta Castelli, Alessandro Porro…·Anna Moroni
This study identifies a recombinant nanobody that specifically activates HCN4 channels and rescues sinus node dysfunction in a patient with a loss-of-function mutation.