Author

Andrea Saponaro

University of MilanORCID 0000-0001-5035-5174Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alessandro PorroiD· 3 shared Anna MoroniiD· 3 shared Gerhard ThieliD· 3 shared Dario DiFrancescoiD· 2 shared Roberta CastelliiD· 2 shared Albano C. MéliiD· 1 shared Alberto Russo· 1 shared Amitav Parida· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiophysics

Alessandro PorroORCID

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3 papers

Recent·Most cited

Comprehensive classification of HCN1 variants linked to neurodevelopmental disorders with and without epilepsy

Roberta Castelli, Carla Marini, Alessandro Porro, Anna Castellini, Greta Fontana, Andrea Saponaro, Gianpiero L. Cavalleri, Susanna Rizzi, Carlo Fusco, Amitav Parida, Richard C. Caswell, Charlotte Sherlaw, Dario Pruna, Christopher A. Reid, Lauren E. Bleakley, , Anna Moroni

This study functionally classifies HCN1 variants in patients with neurodevelopmental disorders, finding genotype-phenotype correlations and potential therapeutic targets.

bioRxiv · Mar 20, 2026 · PreprintPathology

A synthetic potassium channel reduces oxidative stress 1 via cellular adaptronics

Rajesh Khanna, Alberto Russo, Andrea Saponaro, Simone Trini, Tyler S. Nelson, Heather N. Allen, Rebecca Oddone, Chiara Villa, Yvan Torrente, Alessandro Porro, Gerhard Thiel, Anna Moroni

The paper introduces a synthetic potassium channel that senses and mitigates oxidative stress by modulating membrane potential in cells and organelles.

Journal of Pain · Apr 1, 2025Peer-reviewedBiophysics

Animal-free recombinant nanobody rescues HCN4 channel deficit in sinus node dysfunction

Atiyeh Sadat Sharifzadeh, Roberta Castelli, Alessandro Porro, Pietro Mesirca, Romain Perrier, Ana Maria Gomez, Hugo Benoit, Albano C. Méli, Luca Maria Giovanni Palloni, Dario DiFrancesco, Matteo Elia Mangoni, Gerhard Thiel, Andrea Saponaro, Anna Moroni

This study identifies a recombinant nanobody that specifically activates HCN4 channels and rescues sinus node dysfunction in a patient with a loss-of-function mutation.

bioRxiv · Mar 20, 2025 · PreprintBiophysics