Author

Oren Schuldiner

Weizmann Institute of ScienceORCID 0000-0002-7350-9380Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:Drosophila· 5 Approach:experimental assay· 5 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Hagar MeltzeriD· 4 shared Bavat BornsteiniD· 2 shared Gal ShapiraiD· 2 shared Idan Alyagor· 2 shared Alina P. SergeevaiD· 1 shared André FialaiD· 1 shared Barry H. HonigiD· 1 shared El Yazid Rachad· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersNeuroscience

Hagar MeltzerORCID

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Author profile →

5 papers

Recent·Most cited

Branch-specific axon pruning induced by Dpr4/DIP-{Theta} transneuronal interactions

Hagar Meltzer, Shirel Shahar, Alina P. Sergeeva, Bavat Bornstein, Gal Shapira, Phinikoula S. Katsamba, Seetha M. Mannepalli, Fabiana A. Bahna, Noa Moreno, Idan Alyagor, Vicky Berkun, Timothy A. Currier, Lawrence S. Shapiro, Barry H. Honig, Oren Schuldiner

The paper shows Dpr4/DIP-{Theta} transneuronal interactions control branch-specific axon pruning in Drosophila mushroom body neurons, with N-Cadherin mediating this process.

bioRxiv · Mar 31, 2026 · PreprintNeuroscience

Comparative developmental transcriptomics of Drosophila mushroom body neurons highlights the mevalonate pathway as a regulator of axon growth

Lora Fahdan, Hagar Meltzer, Noa Wigoda, Ron Rotkopf, Oren Schuldiner

The paper compares axon growth programs in Drosophila mushroom body neurons using transcriptomics, identifying the mevalonate pathway as critical for axon regrowth.

bioRxiv · Sep 17, 2025 · PreprintNeuroscience

A Drosophila screen of schizophrenia-related genes highlights the requirement of neural and glial matrix metalloproteinases for neuronal remodeling

Shir Keret, Hagar Meltzer, Neta Marmor‐Kollet, Oren Schuldiner

The paper identifies matrix metalloproteinases (MMPs) as critical for neuronal remodeling in Drosophila, linking them to schizophrenia-related genes through a loss-of-function screen.

bioRxiv · Oct 1, 2024 · PreprintNeuroscience

Silencing neuronal activity is required for developmental circuit remodeling

Oded Mayseless, El Yazid Rachad, Gal Shapira, André Fiala, Oren Schuldiner

The paper shows that silencing neuronal activity is required for developmental axon pruning in Drosophila mushroom bodies through a combination of cell autonomous and inhibitory mechanisms.

bioRxiv · Oct 31, 2021 · PreprintNeuroscience

Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons

Bavat Bornstein, Hagar Meltzer, Ruth Adler, Idan Alyagor, Victoria Berkun, Gideon Cummings, Fabienne Reh, Hadas Keren‐Shaul, Eyal David, Thomas Dieter Riemensperger, Oren Schuldiner

The EMBO Journal · Apr 13, 2021Peer-reviewedNeuroscience