Seetha M. Mannepalli

A functional investigation of antibody Fc-FcRn variant binding guided by *in silico* free energy perturbation methods

This paper uses free energy perturbation (FEP) calculations to predict and improve the accuracy of Fc-FcRn binding energy changes due to mutations, incorporating conformational changes and coupling effects.

Branch-specific axon pruning induced by Dpr4/DIP-{Theta} transneuronal interactions

The paper shows Dpr4/DIP-{Theta} transneuronal interactions control branch-specific axon pruning in Drosophila mushroom body neurons, with N-Cadherin mediating this process.

Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations

The paper benchmarks free energy perturbation calculations for predicting mutation effects on protein-protein binding affinity and introduces an automated method to improve accuracy.

Affinity Requirements For Control Of Synaptic Targeting And Neuronal Cell Survival By Heterophilic IgSF Cell Adhesion Molecules

The paper investigates how varying affinities of CAM interactions affect synaptic targeting and neuronal survival in Drosophila, finding different affinity requirements for these processes.

Synaptogenic activity of the axon guidance molecule Robo2 is critical for hippocampal circuit function

This study identifies Robo2 as a synaptogenic molecule critical for excitatory synapse formation and spatial coding in hippocampal circuits.