Author

Karen Schmitt

ORCID 0000-0002-7351-9853Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:imaging· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Johannes H. WilbertziD· 3 shared Peter SommeriD· 3 shared Amélie Weiss· 2 shared David Hoffmann· 2 shared Loïc Cousin· 2 shared Abigail J. Miller· 1 shared Alexandra BenchouaiD· 1 shared Allan Hunter YoungiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Johannes H. WilbertzORCID

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3 papers

Recent·Most cited

Generating Synthetic Task-based Brain Fingerprints for Population Neuroscience Using Deep Learning

Emin Serin, Kerstin Ritter, Günter Schumann, Tobias Banaschewski, André F. Marquand, Henrik Walter, Andreas Heinz, Markus Ralser, Sven Olaf Twardziok, Nilakshi Vaidya, Antoine Bernas, Marcel Jentsch, Esther Hitchen, Elli Polemiti, Hedi Kebir, , George Ogoh

The paper introduces DeepTaskGen, a deep learning method that generates synthetic task-based contrast maps from resting-state fMRI data, outperforming benchmarks and enabling biomarker development for cognitive tasks.

Communications Biology · Nov 14, 2025Peer-reviewedNeuroscience

Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons

Vyron A. Gorgogietas, Amélie Weiss, Loïc Cousin, David Hoffmann, Karen Schmitt, Arnaud Ogier, Peter A. Barbuti, Bruno F. R. Santos, Ibrahim Boussaad, Annika Wittich, Andrea Zaliani, Ole Pleß, Rejko Krüger, Peter Sommer, Johannes H. Wilbertz

The paper identifies compounds that restore morphology in Parkinson's disease neurons by targeting mitochondrial uncoupling.

Scientific Reports · Aug 12, 2025Peer-reviewedNeuroscience

Pharmacological modulation of developmental and synaptic phenotypes in human SHANK3 deficient stem cell-derived neuronal models

Amandine Thibaudeau, Karen Schmitt, Louise François, Laure Chatrousse, David Hoffmann, Loïc Cousin, Amélie Weiss, Aurore Vuidel, Christina B. Jacob, Peter Sommer, Alexandra Benchoua, Johannes H. Wilbertz

This study screens small molecules in SHANK3-deficient neuronal models to identify compounds that rescue developmental and synaptic defects in Phelan-McDermid syndrome.

Translational Psychiatry · Jun 10, 2024Peer-reviewedNeuroscience