Author

Zammy Fairhurst-Hunter

University of Oxford

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3 Genetics· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:GWAS / association mapping· 4 Assay:GWAS summary statistics· 4 Research Focus:fine-mapping· 1 Research Focus:polygenic risk· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Alfred PozarickijiD· 2 shared Canqing YuiD· 2 shared Cassandra Nichole SprackleniD· 2 shared Huaidong DuiD· 2 shared Iona Y. MillwoodiD· 2 shared Jason TorresiD· 2 shared Jesús Alegre-DíaziD· 2 shared Jun LviD· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Alfred PozarickijORCID

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5 papers

Recent·Most cited

Causal relevance of different blood pressure traits on risk of cardiovascular diseases: GWAS and Mendelian randomisation in 100,000 Chinese adults

Alfred Pozarickij, Wei Gan, Kuang Lin, Robert Clarke, Zammy Fairhurst-Hunter, Masaru Koido, Masahiro Kanai, Yukinori Okada, Yoichiro Kamatani, Derrick Bennett, Huaidong Du, Yiping Chen, Ling Yang, Daniel Avery, Canqing Yu, , China Kadoorie Biobank Collaborative Group

This study identifies 128 BP-associated loci in Chinese adults through GWAS and shows causal links between BP traits and CVD using Mendelian randomisation.

Nature Communications · Jul 24, 2024Peer-reviewedGenetic & Genomic Medicine

Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease

Yajie Zhao, Maria Chukanova, Katherine A. Kentistou, Zammy Fairhurst-Hunter, Anna Maria Siegert, Raina Jia, Georgina K.C. Dowsett, Eugene J. Gardner, Felix R. Day, Lena R Kaisinger, Yi‐Chun Loraine Tung, Brian Lam, Hsiao‐Jou Cortina Chen, Quanli Wang, Jaime Berumen-Campos, , John R. B. Perry

The paper identifies protein-truncating variants in BSN associated with severe adult-onset obesity, type 2 diabetes, and fatty liver disease, with no effect on childhood adiposity.

medRxiv · Jun 14, 2023 · PreprintGenetic & Genomic Medicine

Trans-ancestry meta-analysis improves performance of genetic scores for multiple adiposity-related traits in East Asian populations

Zammy Fairhurst-Hunter, Kuang Lin, Iona Y. Millwood, Alfred Pozarickij, Tzu‐Ting Chen, Jason Torres, Jian-an Lun, Christiana Kartsonaki, Wei Gan, Anubha Mahajan, Huaidong Du, Rajani Sohoni, Yu Guo, Sam Sansome, Ling Yang, , Robin G. Walters

This paper improves genetic scores for adiposity traits in East Asian populations by using trans-ancestry meta-analysis, increasing variance explained compared to European-derived scores.

medRxiv · Jul 5, 2022 · PreprintGenetic & Genomic Medicine

A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries

Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, Eric Bartell, Saori Sakaue, Marielisa Graff, Anders Ulrik Eliasen, Yunxuan Jiang, Sridharan Raghavan, Jenkai Miao, Joshua D. Arias, Ronen E. Mukamel, Cassandra Nichole Spracklen, Xianyong Yin, , Thomas Folkmann Hansen

This study identifies 12,111 SNPs associated with height from 5.4 million individuals, explaining most common SNP-based heritability and showing ancestry-specific prediction accuracy.

bioRxiv · Jan 7, 2022 · PreprintGenetics

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Amand Floriaan Schmidt, Michael Vaclav Holmes, David Preiss, Daniel I. Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, R Thomas Lumbers, Albert Henry, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hyppönen, , Albert Hofman D

The paper analyzes genetic variants at the PCSK9 locus to assess their phenotypic effects on lipid levels and disease outcomes, finding concordance with PCSK9 inhibitor trials for myocardial infarction but discordance for type 2 diabetes.

BMC Cardiovascular Disorders · Oct 29, 2019Peer-reviewedGenetics