Author

Kevin W. Chen

Columbia University Irving Medical CenterORCID 0000-0002-7370-3642Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

David Alan BennettiD· 2 shared Hans‐Ulrich KleiniD· 2 shared Mariko F. TagaiD· 2 shared Masashi FujitaiD· 2 shared Philip L. De JageriD· 2 shared Vilas MenoniD· 2 shared Yiyi MaiD· 2 shared Aiqun LiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

David Alan BennettORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature

Victoria S. Marshe, John F. Tuddenham, Kevin W. Chen, Rebecca Chiu, Verena Claudia Haage, Yiyi Ma, Annie Lee, Neil A. Shneider, Julian Agin‐Liebes, Roy N. Alcalay, Andrew F. Teich, Peter Canoll, Claire Riley, Dirk Keene, Julie A. Schneider, , Philip L. De Jager

The paper uses single-cell data to identify factors regulating an Alzheimer's disease-related microglial signature and proposes a new analytic framework for microglial classification.

bioRxiv · Mar 27, 2025 · PreprintNeuroscience

A systems approach uncovers drivers of the multifocal emergence of an astrocyte state contributing to cognitive decline in Alzheimer's disease

Natacha Comandante-Lou, Tsering D Lama, Sarah E. Heuer, Kevin W. Chen, Jinho Kim, Jinglong Zhang, Bin Hu, Shuhui Liu, Swagata Dey, Kristen Brennand, Julie A. Schneider, Lisa L. Barnes, Bin Zhang, Minghui Wang, Hongyan Zou, , Philip L. De Jager

The paper identifies a novel astrocyte state linked to cognitive decline in Alzheimer's disease and validates its regulators through multi-modal analysis and mechanistic experiments.

bioRxiv · Feb 24, 2025 · PreprintNeuroscience