Aiqun Li

The paper investigates how POGZ loss-of-function affects transcription factor binding and gene expression in neurons, revealing shared molecular changes with other NDD-related genes.

The paper identifies a novel astrocyte state linked to cognitive decline in Alzheimer's disease and validates its regulators through multi-modal analysis and mechanistic experiments.

The paper profiles gene expression and chromatin accessibility in 45,549 cortical nuclei across 6 developmental timepoints to study cell fate determination and neuropsychiatric disease mechanisms.

The paper identifies novel autism risk genes by analyzing convergent coexpression patterns in brain samples, showing these genes may not be detected by sequencing studies.

This study shows that schizophrenia risk genes have convergent and non-additive transcriptomic effects when perturbed together in human neurons, suggesting functional redundancy and complex interactions.

The paper examines how ER/mitochondrial coupling changes during human neuronal development and links it to Alzheimer's disease pathology.

This study identifies molecular networks and key regulators in Alzheimer’s Disease using integrative genomics and experimental validation.