This study uses radiomic features from thalamic nuclei to identify associations with cognitive performance in multiple sclerosis patients, finding radiomic features outperform volumetric measures.

Journal of Neuroimaging · Jul 1, 2025Peer-reviewedNeuroscience

A proteogenomic tool uncovers protein markers for human microglial states

Verena Claudia Haage, Alex R. Bautista, John F. Tuddenham, Victoria S. Marshe, Rebecca Chiu, Yunduo Liu, Tsering Lama, Shane S. Kelly, Neelang Parghi, Junho Park, Alice Buonfiglioli, Julia Lynn Furnari, Imdadul Haq, Richard V. Pearse, Ronak Patel, , Philip L. De Jager

The paper introduces a proteomic tool to identify protein markers for human microglial states and validates their utility in purification and differentiation.

bioRxiv · Mar 31, 2025 · PreprintNeuroscience

A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature

Victoria S. Marshe, John F. Tuddenham, Kevin W. Chen, Rebecca Chiu, Verena Claudia Haage, Yiyi Ma, Annie Lee, Neil A. Shneider, Julian Agin‐Liebes, Roy N. Alcalay, Andrew F. Teich, Peter Canoll, Claire Riley, Dirk Keene, Julie A. Schneider, , Philip L. De Jager

The paper uses single-cell data to identify factors regulating an Alzheimer's disease-related microglial signature and proposes a new analytic framework for microglial classification.

bioRxiv · Mar 27, 2025 · PreprintNeuroscience

A structured evaluation of cryopreservation in generating single cell transcriptomes from cerebrospinal fluid

Hanane Touil, Tina Roostaei, Daniela Calini, Claudiu I. Diaconu, Samantha Epstein, Catarina Raposo, Kaho B. Onomichi, Kiran Teresa Thakur, Licínio Craveiro, Ilaria Callegari, Julien Bryois, Claire Riley, Vilas Menon, Tobias J Derfuss, Philip L. De Jager, Dheeraj Malhotra

This study evaluates a cryopreservation protocol for CSF cells, showing it preserves cell composition and transcriptomes effectively, enabling multi-center research.

Cell Reports Methods · Jul 1, 2023Peer-reviewedGenetics