Author

Dirk Keene

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:clustering· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Assay:scRNA-seq· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Owen A. RossiD· 2 shared Adriano AguzziiD· 1 shared Alan J. ThomasiD· 1 shared Alberto RábanoiD· 1 shared Alex H. RajputiD· 1 shared Alexander Y. PantelyatiD· 1 shared Ali H. Rajput· 1 shared Allison BelleriD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Owen A. RossORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A factor-based analysis of individual human microglia uncovers regulators of an Alzheimer-related transcriptional signature

Victoria S. Marshe, John F. Tuddenham, Kevin W. Chen, Rebecca Chiu, Verena Claudia Haage, Yiyi Ma, Annie Lee, Neil A. Shneider, Julian Agin‐Liebes, Roy N. Alcalay, Andrew F. Teich, Peter Canoll, Claire Riley, Dirk Keene, Julie A. Schneider, , Philip L. De Jager

The paper uses single-cell data to identify factors regulating an Alzheimer's disease-related microglial signature and proposes a new analytic framework for microglial classification.

bioRxiv · Mar 27, 2025 · PreprintNeuroscience

Genome-wide association study of autopsy-confirmed Multiple System Atrophy identifies common variants near ZIC1 and ZIC4

Franziska Hopfner, Anja K. Tietz, Viktoria Ruf, Owen A. Ross, Shunsuke Koga, Dennis W. Dickson, Adriano Aguzzi, Johannes Attems, Thomas Beach, Allison Beller, William P. Cheshire, Vivianna M. Van Deerlin, Paula Desplats, Günther Deuschl, Charles J. Duyckaerts, , Günter U. Höglinger

Movement Disorders · Aug 23, 2022Peer-reviewedGenetic & Genomic Medicine

Systematic analysis of dark and camouflaged genes: disease-relevant genes hiding in plain sight

Mark Ebbert, Tanner D. Jensen, Karen R. Jansen‐West, Jonathon P. Sens, Joseph S. Reddy, Perry G. Ridge, John S. K. Kauwe, Véronique Belzil, Luc Pregent, Minerva M. Carrasquillo, Dirk Keene, Eric Berg Larson, Paul K. Crane, Yan W. Asmann, Nilüfer Ertekin‐Taner, , John Denis Fryer

The paper identifies dark and camouflaged gene regions in the human genome, shows how long-read sequencing reduces their prevalence, and applies an algorithm to uncover disease-relevant variants in Alzheimer's Disease Sequencing Project data.

Genome biology · May 19, 2019Peer-reviewedGenomics