Maxime W.C. Rousseaux

This paper introduces a refined CRISPR screening protocol to compare cellular responses across multiple stressors, reducing false positives by 40% through fluorescence-based reporters and fixation steps.

The paper identifies stress-specific autophagy regulators using CRISPR screens, finding unique kinases for ER-phagy and pexophagy.

This study shows that TDP-43 SUMOylation is a stress response that protects neurons, and its disruption is linked to aging and disease.

This study surveys Canadian early-career health researchers to assess pandemic impacts, revealing high burnout rates and mental health declines.

This study examines neuropathological changes in the olfactory bulb and tract of COVID-19 patients, finding no significant inflammation but age-related decline in anti-CD68 reactivity and mild increases in phospho-Syn and phospho-tau signals in affected brains.

This study shows that reducing CDK14 genetically or pharmacologically decreases alpha-synuclein pathology and improves symptoms in Parkinson's disease models.

This study maps the expression and dosage of alpha-Synuclein across cell types in the mouse brain and periphery, identifying high and low expressing cell types and their potential role in Parkinson's disease.

The paper characterizes the differential distribution and targets of Sumo paralogs in the mouse brain using knock-in mouse models and proteomic analysis.

This study investigates how alpha-synuclein aggregation in the basolateral amygdala affects glutamatergic transmission, finding that it selectively disrupts cortico-BLA synapses.

CRISPRCloud2 provides a cloud-based platform for deconvoluting CRISPR screen data with tools for read mapping, statistical analysis, visualization, and integration with other resources.

This study shows that reducing Trim28 in adult mice is safe and lowers levels of alpha-synuclein and tau.

SAVE provides a cloud-based pipeline for deconvolving CRISPR pooled screening data, enabling analysis and visualization of NGS files through a secure web platform.