Payton A. B. Weidenbacher

A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses

This paper develops a stabilized MERS-CoV spike ferritin nanoparticle vaccine that elicits strong neutralizing antibodies in mice and non-human primates, providing protection against MERS-CoV infection.

Design, Structure, and Immunogenicity of a Soluble Prefusion-stabilized EBV gB Antigen

This study designs and characterizes a prefusion-stabilized EBV gB antigen, showing improved immunogenicity and structural insights for vaccine development.

Engineering a SARS-CoV-2 vaccine targeting the RBD cryptic-face via immunofocusing

This study uses the PMD immunofocusing technique to create RBD immunogens that induce broadly neutralizing antibodies against the conserved cryptic face of SARS-CoV-2.

Efficient evolution of human antibodies from general protein language models and sequence information alone

Consensus likelihoods from general, unsupervised protein language models evolve seven human antibodies using only a wildtype sequence and <=20 tested variants, improving binding affinity up to 160-fold.