Author

Sofia I. Picucci

University of California, IrvineORCID 0009-0004-2173-3497Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Angela Lackner· 2 shared Karen Wang· 2 shared Reginald McNultyiD· 2 shared Valerie Henriquez· 2 shared Abigail E. PowelliD· 1 shared Alijah Macapagal· 1 shared Brad A. PalanskiiD· 1 shared Chia‐Wei ChouiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

Angela Lackner

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950

Angela Lackner, Sofia I. Picucci, Wenjin Jiang, Janset Onyuru, Melissa Campos, Julia Elise Cabral, Lemuel Leonidas, Alijah Macapagal, Hannah J. Lee, Valerie Henriquez, Karen Wang, Huilin Xu, Yanfei Qiu, Lauren Veronica Albrecht, Hal M. Hoffman, Reginald McNulty

This paper shows that TH5487 and SU0268 inhibit NLRP3 activation in FCAS patient PBMCs, overcoming resistance to MCC950 by blocking inflammasome assembly and reducing IL-1β secretion.

Communications Biology · Apr 16, 2026Peer-reviewedImmunology

RM1mAb avoids Intracellular degradation to Synergistically inhibit NLRP3 Inflammasome Activation in Familial Cold Autoinflammatory Syndrome

Angela Lackner, Sofia I. Picucci, Valerie Henriquez, Karen Wang, Reginald McNulty

RM1mAb and TH5487 synergistically inhibit inflammasome activation in human FCAS PBMCs by preventing NLRP3-mtDNA interaction and avoiding lysosomal degradation.

bioRxiv · Dec 12, 2025 · PreprintImmunology

Design, Structure, and Immunogenicity of a Soluble Prefusion-stabilized EBV gB Antigen

Ryan S. McCool, Cory M. Acreman, Abigail E. Powell, Sofia I. Picucci, Daniel J Stieh, Jeremy Huynh, Hannah Caruso, Soyoon Park, Jessica O’Rear, Jui‐Lin Chen, Brad A. Palanski, Patrick O. Byrne, Madeline R. Sponholtz, Chia‐Wei Chou, Jeongryeol Kim, , Jason S. McLellan

This study designs and characterizes a prefusion-stabilized EBV gB antigen, showing improved immunogenicity and structural insights for vaccine development.

bioRxiv · May 19, 2025 · PreprintBiochemistry