Author

Elena Chrysostomou

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Bioinformatics· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Research Focus:database / resource· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

Angelika DoetzlhoferiD· 2 shared Anup MahurkariD· 2 shared Brian R. HerbiD· 2 shared Carlo ColantuoniiD· 2 shared Dustin OlleyiD· 2 shared Joshua OrvisiD· 2 shared Ricky S. AdkinsiD· 2 shared Robert L. CarteriD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersDevelopmental Biology

Angelika DoetzlhoferORCID

Author profile →

5 papers

Recent·Most cited

An Open-Source Deep Learning-Based Toolbox forAutomated Auditory Brainstem Response Analyses (ABRA)

Abhijeeth Erra, Cayla M. Miller, Jeffrey Chen, Elena Chrysostomou, Shannon Barret, Yasmin M. Kassim, Rick Adam Friedman, Amanda M. Lauer, Federico Ceriani, Walter Marcotti, Cody Carroll, Uri Manor

ABRA automates ABR waveform analysis using deep learning, achieving performance comparable to human experts while improving reproducibility and reducing analysis time.

Scientific Reports · Feb 19, 2026Peer-reviewedNeuroscience

The Notch ligand Jagged1 plays a dual role in cochlear hair cell regeneration.

Xiaojun Li, Charles Morgan, Lin Li, Wanyu Zhang, Elena Chrysostomou, Angelika Doetzlhofer

This study shows that Jagged1/Notch signaling maintains cochlear supporting cell progenitor-like characteristics and metabolic genes, and its inhibition enhances hair cell regeneration.

Nature Communications · Sep 1, 2025Peer-reviewedDevelopmental Biology

The Neuroscience Multi-Omic Archive: A BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain

Seth A. Ament, Ricky S. Adkins, Robert Carter, Elena Chrysostomou, Carlo Colantuoni, Jonathan Crabtree, Heather H. Creasy, Kylee Degatano, Victor Felix, Peter Gandt, Gwenn A. Garden, Michelle Gwinn Giglio, Brian R. Herb, Farzaneh Khajouei, Elizabeth A. Kiernan, , Owen R. White

The paper describes the Neuroscience Multi-Omic Archive, a repository for single-cell transcriptomic and epigenomic data from mammalian brains, providing tools for data access and analysis.

Nucleic Acids Research · Nov 1, 2022Peer-reviewedGenomics

gEAR: gene Expression Analysis Resource portal for community-driven, multi-omic data exploration

Joshua Orvis, Brian Gottfried, Jayaram Kancherla, Ricky S. Adkins, Yang Song, Amiel A. Dror, Dustin Olley, Kevin P. Rose, Elena Chrysostomou, Michael C. Kelly, Beatrice C. Milon, Maggie S. Matern, Héla Azaiez, Brian R. Herb, Carlo Colantuoni, , Ronna P. Hertzano

gEAR provides a community-driven portal for multi-omic data visualization, analysis, and sharing across species and data types.

Nature Methods · Jun 25, 2021Peer-reviewedBioinformatics

The Notch Ligand Jagged1 is Required for the Formation, Maintenance, and Survival of Hensen Cells in the Mouse Cochlea

Elena Chrysostomou, Luyi Zhou, Yuanzhao L. Darcy, Kaley A. Graves, Angelika Doetzlhofer, Brandon C. Cox

This study shows that Jagged1 is essential for forming and maintaining Hensen cells in the mouse cochlea, with its loss leading to cell death or conversion into Claudius cells.

Journal of Neuroscience · Oct 30, 2020Peer-reviewedDevelopmental Biology