Author

Karl J. Simin

University of Massachusetts Chan Medical SchoolORCID 0000-0002-7431-0939Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jason Robert PitarresiiD· 2 shared Jessica PeuraiD· 2 shared Marcus A. RuscettiiD· 2 shared Anil K. RustgiiD· 1 shared Arthur M. MercurioiD· 1 shared Ben Z. StangeriD· 1 shared Calvin W. JohnsoniD· 1 shared Emma Elizabeth FurthiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCancer Biology

Jason Robert PitarresiORCID

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2 papers

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedSep 3, 2025

MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer

Katherine C. Murphy, Kelly D. DeMarco, Lin Zhou…·Marcus A. Ruscetti

This study shows that MYC and p53 alterations in prostate cancer cooperate via VEGF signaling to suppress T cell activity and immunotherapy responses, and that targeting VEGFR2 can enhance immunotherapy efficacy.

10 citationstop 5%

mousehuman

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Cancer BiologyCell ReportsPeer-reviewedApr 24, 2025

Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity

Jillian Weissenrieder, Jessica Peura, Usha Paudel…·J. Kevin Foskett

This study shows that mitochondrial Ca2+ uptake via MCU promotes pancreatic cancer growth and metastasis by enhancing epithelial plasticity through EMT.

13 citations

mouseexperimental assay

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