Anil K. Rustgi

Mutant p53 regulates cancer cell invasion in complex three-dimensional environments through mevalonate pathway-dependent Rho/ROCK signaling.

This study shows mutant p53 promotes cancer cell invasion in 3D environments via mevalonate pathway-dependent Rho/ROCK signaling and ECM reorganization.

Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity

This study shows that mitochondrial Ca2+ uptake via MCU promotes pancreatic cancer growth and metastasis by enhancing epithelial plasticity through EMT.

Knowledge Discovery in Datasets of Proteomics by Systems Modeling in Translational Research on Pancreatic Cancer

The paper proposes a systems modeling workflow for knowledge discovery in proteomics datasets, applied to pancreatic ductal adenocarcinoma to identify translational targets and pathways.